PLoS ONE 17(3):Įditor: Feng Gao, Tianjin University, CHINA This study illustrates the importance of environmental surveillance of biocide-resistance in veterinary hospitals.Ĭitation: Allen JL, Doidge NP, Bushell RN, Browning GF, Marenda MS (2022) Healthcare-associated infections caused by chlorhexidine-tolerant Serratia marcescens carrying a promiscuous IncHI2 multi-drug resistance plasmid in a veterinary hospital. A chlorhexidine-tolerant Serratia isolate which lacked the IncHI2 plasmid was used in mating experiments to demonstrate the transfer of multi-drug resistance from a E.
IncHI2 plasmids are commonly found in Enterobacteriaceae, but are rarely present in Serratia spp., suggesting that this plasmid was acquired from another organism. This replicon was highly similar to a plasmid previously detected in a strain of Enterobacter hormaechei recovered from the Hospital environment. The nine multi-drug resistant Serratia isolates also possessed a Ser-83-Ile mutation in GyrA conferring fluoroquinolone resistance, and carried a large IncHI2 conjugative plasmid encoding antimicrobial and heavy metal resistances. A genomic island encoding a homolog of the Pseudomonas MexCD-OprJ biocide efflux system was detected in the chlorhexidine-tolerant Serratia. with a similar resistance profile was also isolated from chlorhexidine solutions used across the Hospital, suggesting that these infections had a nosocomial origin. Nine quasi-clonal isolates associated with post-surgical complications in different patients displayed high levels of resistance to the antimicrobials fluoroquinolones, cephalosporins, aminoglycosides, and to the disinfectant chlorhexidine. ureilytica (n = 3) and were placed into four distinct phylogenetic groups. isolated from dogs, cats, horses, a bird and a rabbit examined at an Australian veterinary hospital between 20 were characterised. The phenotypes and genotypes of Serratia spp. In veterinary settings, the diversity, reservoirs and modes of transmission of this pathogen are poorly understood. The bacterium Serratia marcescens can cause opportunistic infections in humans and in animals.
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